THE ENZYMATIC DEGRADATION OF THYMONUCLEIC ACID
نویسندگان
چکیده
منابع مشابه
The enzymatic degradation of thymonucleic acid. I. The preparation of oligonucleotides.
This study constitutes the first phase of an investigation undertaken to develop a method for obtaining mononucleotides from the desoxyribonucleic acid of calf thymus, and concerns itself with the first step in the procedure, namely the production of oligonucleotides. Fischer, LehmannEchternacht, and Boettger (1) have studied the degradation of thymonucleic acid, prepared by Levene’s (2) method...
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The earlier work on thymonucleic acid by Levene and Mandell and by Levene and Jacobs2 led to the isolation of monophosphoric esters of pyrimidine nucleosides and diphosphoric esters of pyrimidine nucleosides. These observations were corroborated by Thannhauser and coworkers.3 In a recent publication Levene and London4 reported the isolation of a guanine nucleoside and the present paper contains...
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Urocanic acid, produced by the nonoxidative deamination of L-histidine, has been demonstrated as the first intermediate in the degradation of this amino acid in liver (l-6) and in microorganisms (7-9). The subsequent enzymatic degradation of urocanic acid yields ol-r-formamidinoglutaric acid (10-13). The present paper describes the enzymatic formation of an unstable intermediate in this reactio...
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Erythrocytes containing pig liver uricase have been prepared by hypotonic hemolysis in the presence of the enzyme. Uricase is shown to be active within the erythrocytes and to degrade uric acid as rapidly as it enters the cells when high intracellular enzyme concentrations are employed. The kinetics and characteristics of uric acid entry are shown to be the same for hemolysed and normal erythro...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1951
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)77742-4